Pilot - Air date 11/06/04

A young kindergarten teacher, Rebecca Adler, who suffers from seizures collapses in her classroom after uncontrolled gibberish slips out her mouth while she is about to teach her students. She is taken to Dr, House and his team of experts who identify it might be a tumor, and she might have only a week to live.

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A 16-year old high school student, Dan, starts suffering from nightmares and frequent hallucinations, and he reveals he was hit in the head while playing lacrosse at school. Dan is apparently suffering from MS, and risky brain surgery is needed. Meanwhile House must deal with a patient looking to set up a lawsuit and a mother who doesn't believe in vaccinations.

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A college student collapses after rowdy sex with his girlfriend. Dr. House and his team are trying to figure out why he collapsed while his conditions seemed to get worse hour by hour, and he has too many symptons to determine the disease.

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When a virus is spreading among the hospital, infecting six babies, House and his team must make decisions that could compromise the lives of the babies.

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House and the crew encounter a nun whose hands are red, swollen, and cracked, and in the middle of the palm the skin is almost fully peeled off and bleeding. They believe it was a case of Stigmata or just an allergic reaction to dish soap or another source. So Dr. House prescribes her some pills, but she also has asthma so, the Nun is fighting for air just minutes later. Dr. House has to inject her with Epinefrine to help her lungs get looser. Hour by Hour shes getting weaker, so her sisters, Sister Eucharist and Sister Pius, pray for her.

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Dr. House is intrigued by the symptoms of a schizophrenic woman, who displays mixed symptoms, including a tumor, but soon realizes the source of her problems isn't the obvious. House confronts his birthday and Chase confronts his past when the mother's son tries to keep up with her condition.

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Two men are out jogging - one of them returns back to his wife and discovers her dead asleep and brings her to the clinic. The doctors are puzzled by her symptoms, and consider everything from tumors to breast cancer to rabbit fever. When all the treatments fail, House concludes she has African sleeping sickness...but neither the woman or her wife could possibly have got it on their own. The woman will die without the proper treatment...but neither one admits to getting it through sex with someone else

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When a high school student falls victim to a mysterious but lethal poisoning, House and his team jump in to find out what is killing the teen. Given a low heart rate and a clean tox screen, House sends Cameron and Chase to the teen's home to find the hot new drug House is sure he's taking. They don't find any drugs, but think they've come up with the answers, until a second unrelated student is admitted with identical symptoms. With the boys' lives hanging in the balance, House and the team have to connect the dots – fast. Meanwhile, an 82-year-old patient has become enamored with House while he helps her figure out the basis of her renewed fascination with her sexual feelings.

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Legendary jazz musician John Henry Giles is checked into the clinic and when he's told he's dying from ALS, he signs a DNR to avoid a slow death. House disagrees with the diagnosis and goes against everyone's wishes when he violates the DNR to save Giles' life. The decision lands House in court, drives Foreman to consider taking another job, and results in Giles' paralysis worsening. But when the patient inexplicably starts getting better, the team has to figure out the mystery in reverse and find out why his condition is improving. Meanwhile, Dr. Foreman meets with an old friend who offers him a West Coast partnership

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Dr. Foreman believes an uncooperative homeless woman is faking seizures to get a meal ticket at the teaching hospital. But her homelessness strikes a personal chord with Dr. Wilson and he grows determined to keep her from falling between the cracks. Her worsening symptoms prove to be a complex mystery for House and his team, but the mystery of her identity and medical history may hold the answers to saving her life. Just as the team suspects she has contagious meningitis, the woman goes missing, only to be tasered by the police, who bring her back. But House deduces the taser may have proven yet another diagnosis, with dire results. Meanwhile, House has an audience of two medical students who are learning how to do case studies.

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While trying to figure out why a young patient won't stop bleeding after a car wreck, House takes Cuddy's challenge and goes off Vicodin for a week in exchange for no clinic duty for a month. If House and his team can't determine the source of his patient's blood loss, the 16-year-old car victim will die in a matter of days. As House's withdrawal symptoms become more and more severe, his patient directives for his patient are more harsh and risky than usual, and Foreman and Cameron are afraid he may not be thinking clearly enough to save the patient's life.

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A severely broken arm reveals a bizarre case of bone loss and ends the comeback plans of major league pitcher Hank Wiggen. House suspects Hank – with a history of drug abuse – is lying about using steroids, as his condition worsens. When Hank's kidneys start to fail, his wife offers to donate hers, but she would have to abort her early pregnancy. Forced into an impossible solution, and admitting failure as an addict, Hank tries to take his own life. House and his team must isolate and fix the problem soon if this pitcher's life, as well his career, can be saved. Meanwhile, Foreman dates a pharameutical representative and House is stuck with two tickets and ends up going on a "date" with Cameron...to a monster truck rally.

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A 12-year-old boy believes he's cursed after a Ouija board tells him he's going to die. His father, a major financial supporter of the hospital, makes escalating demands of House and the team as they try to diagnose the boy's pneumonia-like symptoms and incongruous rash. Tension intensifies when House invites Chase's estranged father, a renowned doctor visiting from Australia, into their circle of diagnosticians – much to Chase's discomfort – and House is intrigued by Chase's lack of relationship with his father. When the boy's diagnosis becomes more evident, the young patient is forced to face the idea that his father may not be everything he believes.

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Princeton-Plainsboro Teaching Hospital is turned upside-down when billionaire entrepreneur Edward Vogel spends $100 million on the clinic and becomes the new Chairman of the Board. Vogler intends to use the hospital as a new biotech venture and plans to eliminate the financially draining services of one Dr. House. Meanwhile, a powerful young woman who seemingly has it all – perfect life, perfect body, perfect job – becomes inexplicably paralyzed. Upon discovering her deadly secret, House finds himself fighting for her life even though it means risking his job and his medical license.

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Just before mobster Joey Arnello spills the beans in federal court and enters witness protection, he collapses. Is he faking? A court order instructs House to find out – and fast. House and his team struggle to diagnose and cure Joey while Joey's brother Bill tries to slow things down and keep Joey from testifying. Meanwhile, Cuddy struggles to convince Vogler that House is an essential part of the hospital.

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House must fire one of his doctors and leaves them to think about it while they deal with an overweight 10-year old child who suffered a heart attack as the result of taking diet pills. House is also faced with a woman who won't accept surgery for a 30 lb. tumor because she wants to remain overweight.

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While Vogler offers House a deal to get out of laying off a staff member, the doctors must deal with a senator who refuses to believe House's diagnosis of AIDS.

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House must deal with two patients - a pregnant woman who is having trouble swallowing and an underweight baby. But he may have more to worry about from Vogler, who is after House and anyone else who gets in his way.

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When a meningitis outbreak sweeps the cllinic, one 12-year old diver shows additional symptoms that endanger his life.

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While Princeton-Plainsboro Hospital is rife with rumor and speculation about House's imminent date with Cameron, House apparently scares a meek clinic patient into having a stroke. The team must navigate their way through the patient's odd proclivities, overbearing "friend" and reluctant parents in order to stop the strokes and try to save the guy's life. All the while, Wilson, Cuddy and the team offer House dating advice and lay odds on the outcome.

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House's ex-girlfriend Stacy Warner returns – not for House but to get help for her ailing husband. While House decides whether or not to take her case, Cuddy forces him to present a lecture to a class of medical students. As he weaves the stories of three patients ho all present with a similar symptom, House gives a lecture the students will never forget.

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TV Guide, May 22, 2005:

When Stacy insists her husband Mark get tests, House insists he can handle things. But despite the fact Mark's tests prove negative, his steadily growing symptoms indicate he is dying. While House struggles with the mystery and make increasing demands on his staff, Wilson worries about House's emotional well-being, and Cuddy considers adding a new employee to the clinic.

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